tag:blogger.com,1999:blog-17962228960240525592024-03-20T12:14:42.482+03:00Treatment For ThalassemiaAbout thalassemia patient, including information on symptoms, diagnosis, treatments, prevention, tests, surgical procedures, and complication. Also we give you how Thalassemia became carrier on family members.cantikhttp://www.blogger.com/profile/04413983402238496919noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-1796222896024052559.post-63692931173121946902013-08-06T01:31:00.002+03:002013-08-06T01:31:21.409+03:00Medication Therapy for Treatment of Thalassemias<div dir="ltr" style="text-align: left;" trbidi="on">
Thalassemia disease is a group of inherited autosomal recessive blood disorders, in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen thus causing anemia, the characteristic presenting symptom of the thalassemias. Patient with <a href="http://treatment-thalassemia.blogspot.com/2011/07/diet-and-weight-loss-for-your-healthy.html">thalassemia</a> will get regular blood transfusion to treat his anemia, These transfusions can lead to a build-up of iron which can be harmful and this can cause serious side effects including diabetes, heart failure and liver disease.
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The iron overload related to thalassemia may be treated by chelation therapy with medications such as Desferrioxamine, Deferiprone or Deferasirox. Medications therapy in thalassemia can be used to remove excess iron from the blood, This may have severe side effects and must be carefully monitored.
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Deferoxamine is an intravenously administered chelation agent currently approved for use in the United States. This medicine only effective via daily injections which makes its long term use more difficult. It is also used with other medicines to treat acute iron poisoning, especially in small children. Deferoxamine (also known as desferrioxamine B, desferoxamine B, DFO-B, DFOA, DFB or desferal) is a bacterial siderophore produced by the actinobacteria Streptomyces pilosus. Using this medicine, It is common to develop pain, swelling, itchiness and redness at the site of the injection, nausea and headache.
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Deferiprone is given as an oral medication. Generic name is (de-FER-i-prone), and brand Name is Ferriprox. The therapy is being approved under the U.S. Food and Drug Administration (FDA) in October 2011. Some side effects of deferiprone may not be reported, but some little cases of side effects include: Nausea, vomiting and diarrhea. Potentially, the most serious side effect of DFP is agranulocytosis (a condition where bone marrow no longer produces enough white blood cells).
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Desferasirox has the benefit of being an oral medication. Brand name or marketed as Exjade. This medicine is indicated for the treatment of chronically elevated levels of iron in the blood caused by regular blood transfusions in thalassemias patient, especially for 2 years of age and older. It was approved by the United States Food and Drug Administration (FDA) in November 2005. By taking this medication, may risk to get side effects include nausea, vomiting, diarrhea, stomach pain, increases in kidney laboratory values, and skin rash.
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The other medication therapy for <a href="http://disease-treatment.blogspot.com/2011/08/disease-and-treatment-of-thalassemia.html">thalassemia disease</a> still under research. The long-term hope is that thalassemia major will be cured by insertion of the normal beta-chain gene through gene therapy or by another modality of molecular medicine. Source : <a href="http://en.wikipedia.org/wiki/Thalassemia" target="new">Wikipedia</a>, <a href="http://emedicine.medscape.com/article/206490-medication" target="new">eMedicine</a>, <a href="http://www.nhlbi.nih.gov/health//dci/Diseases/Thalassemia/Thalassemia_Treatments.html" target="new">NHLBI</a>, <a href="http://www.sciencedaily.com/releases/2010/07/100713171559.htm" target="new">SienceDaily</a>.</div>
cantikhttp://www.blogger.com/profile/04413983402238496919noreply@blogger.com0tag:blogger.com,1999:blog-1796222896024052559.post-61178780204803239762013-08-04T21:24:00.003+03:002013-08-04T21:24:44.037+03:00Treatment For Thalassemia by Bone Marrow Transplant<div dir="ltr" style="text-align: left;" trbidi="on">
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The Bone Marrow Transplantation (<a href="http://www.curethalassemia.org/bone-marrow-transplantation-bmt/" target="new">BMT</a>) Service is a medical treatment that dedicated to providing exceptional patient care and novel treatment options for patients with malignant and benign diseases of the blood-building system who require an autologous or allogeneic transplant. The BMT are common procedures for <a href="http://treatment-thalassemia.blogspot.com/">treatment of Thalassemia</a>. A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells.
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Bone marrow is found inside the bones and is the origination of stem cells that create red blood cells, white blood cells, and platelets. Stem cells are immature cells in the bone marrow that give rise to all of your blood cells. There are two types of Bone Marrow Transplants; Autologous bone marrow transplant and Allogenic bone marrow transplant.
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In Autologous bone marrow transplant procedure is a type of transplant that uses the patient's bone marrow (him self) to replace damaged or destroyed of bone marrow. <a href="http://www.ncbi.nlm.nih.gov/pubmed/16339666" target="new">Allogeneic</a> bone marrow transplant, "Allo" means "other." So on this procedure the doctor will do the BMT from other person whose tissue has the same genetic type as the person needing the transplant (recipient).
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Treatment For Thalassemia by Bone Marrow Transplant need to extra attention, there are some stage to be done by medical team before this action that called as transplant procedure ;<br />
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<li>A physical examination to assess your general level of health</li>
<li>Obtaining the stem cells to be used in the transplant (known as harvesting)</li>
<li>Preparing your body for the transplant (known as conditioning)</li>
<li>Transplanting the stem cells</li>
<li>The recovery period during which you will be monitored for any complications or side effects</li>
<li>Before the transplant, chemotherapy, radiation, or both should be given.</li>
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Sources of Bone Marrow Stem Cells :
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<li>Bone marrow harvest: Collecting stem cells by taking them directly out of the bone.</li>
<li>Bone marrow Apheresis: Collecting stem cells by filtering the blood for peripheral (circulating) blood cells (PBSC).</li>
<li>Umbilical cord blood: Stem cells are filtered from blood in the umbilical cord after a baby is born.</li>
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To remove the marrow, the doctor puts a needle through the skin into the hip bone (pelvis), of course after the patient got a general anaesthetic. Occasionally, the doctor uses the chest bone (sternum) also. Patient Thalassemia who received bone marrow transplant can be an intensive and challenging experience (about 40-45 days stay in hospital), It take up to a year to fully recover from the procedure. The success of a transplant depends on the type and stage of the <a href="http://disease-treatment.blogspot.com/2011/08/disease-and-treatment-of-thalassemia.html">disease</a> and your age and general health.</div>
cantikhttp://www.blogger.com/profile/04413983402238496919noreply@blogger.com1tag:blogger.com,1999:blog-1796222896024052559.post-10394381270688703842013-08-02T15:23:00.000+03:002013-08-02T15:24:12.554+03:00Treatment For Thalassemia by Hematopoietic Stem Cell Transplant<div dir="ltr" style="text-align: left;" trbidi="on">
A stem cell transplant is the only treatment that can cure thalassemia, this treatment is to replace or to repair a patient’s cells or tissues that are damaged with healthy ones from another person (a donor). For patients who do not have such a donor in the family, an unrelated volunteer donor can be used. Stem cells are the cells inside bone marrow that make red blood cells and other types of blood cells. Stem cells have the remarkable potential to develop into many different cell types in the body.
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Hematopoietic stem cell transplantation (HSCT) has become an accepted method of therapy for the <a href="http://disease-treatment.blogspot.com/2011/08/disease-and-treatment-of-thalassemia.html">treatment of thalassemia</a>, by stem cell transplantation is the basis of treatment that is being studied in the last two decades due to improvements in preventive strategies, and effective control of transplant-related complications. The rate of rejection/thalassemia recurrence was much higher in thalassemic patients than in patients transplanted because of malignancies.
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Many people they don't know the benefit of treatment by Stem Cell transplant's method. This system already have many applications for treating diseases for example; cancer, Type 1 diabetes mellitus, Parkinson's disease, Huntington's disease, Celiac disease, cardiac failure, muscle damage and neurological disorders, and many others including thalassemia.
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Although this treatment is a good action for the patients with Thalassemia, but still there are several risks associated with the procedure. Some of the complications that can occur with a stem cell transplant are; damage to organs or blood vessels, Graft versus host disease and Death. In most cases, the benefits treatment by <a target="new" href="http://www.ncbi.nlm.nih.gov/pubmed/22553502">stem cell</a> transplants will likely outweigh the risk of complications and these techniques can truly be life-saving for conditions such as leukaemia and aplastic anaemia.
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Hematopoietic Stem Cell Transplant will completely alter the way for the medical team who want to do practice medicine. Actually to do the treatment for <a target="new" href="http://www.slideshare.net/aabbccddeeee/stem-cell-transplantation-in-thalassemia">thalassemia patient</a> with this system is not easy, some patients are not able to find a donor who is perfectly matched for all HLA (Human Leukocyte Antigens) molecules. But in this situation, mostly the doctors will continue on their planning with a donor whose HLA molecules are not all the same as those of the recipient, even though this increases the chance of rejection or GvHD (Graft-versus-Host Disease) after the transplantation.</div>
cantikhttp://www.blogger.com/profile/04413983402238496919noreply@blogger.com0tag:blogger.com,1999:blog-1796222896024052559.post-9965987735616146802013-08-02T04:24:00.002+03:002013-08-02T15:24:44.448+03:00Treatment For Thalassemia By Regular Blood Transfusions<div dir="ltr" style="text-align: left;" trbidi="on">
Thalassemia Disease is a genetic blood disorder that affects the production of the hemoglobin, the oxygen carrying component of the red blood cell in the human body. Treatment for <a href="http://disease-treatment.blogspot.com/2011/08/disease-and-treatment-of-thalassemia.html">thalassemia</a> depends on patient condition, usually the medical team take an action due to subtype of the disorder, but may include treatment for anemia, blood transfusions, and treatment for the effects of blood transfusions, such as iron overload.
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Patients with Thalassemia who getting treatment by regular Blood transfusions system commonly they have serious situation for life-threatening due too anemia. There are two form of <a href="http://www.nurse-ocha.com/2006/10/thalassemia.html">Beta Thalassemia</a> that need to get treatment by regular Blood transfusions; Thalassemia Intermedia (TI) and Thalassemia major (Cooley's anemia). This treatment gives a patient healthy red blood cells with normal hemoglobin.
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Beta thalassemia intermedia and major can lead to serious complications, especially if untreated. Some of complication may occurs Excess iron, Bone deformities and broken bones, Enlarged spleen, Infections, Slower growth rates. The doctor will decided a regular transfusion program in a child newly diagnosed with thalassemia must take into account both laboratory and clinical findings. Children with <a href="http://health.nytimes.com/health/guides/disease/thalassemia" target="new">thalassemia major</a> require ongoing treatment and blood transfusions to stay healthy.
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Treatment of Thalassemia by regular blood transfusions system can lead to a buildup of iron in the blood (iron overload), Without removal of this iron by chelation, it can become toxic to several vital organs such as damages the liver, heart, and other parts of the body. Frequency of transfusion usually every two to three weeks to maintain the pre-transfusion haemoglobin level above 9–10.5 g/dl, it will take 1 to 4 hours. Patient with cardiac insufficiency, transfusion may have to be given every second week or sometime every week.
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The risk of transfusion in transmitted infections for the <a href="http://www.thalassemicsindia.org/news.html" target="new">thalassemia patients</a> are malaria, syphilis, hepatitis B and C, Cytomegalovirus, and HIV infection. Other reaction from blood transfusion may occurs sudden development hypertension, convulsion, cerebral hemorrhage, and edema after multiple transfusion. Transfusions of washed, leukocyte-depleted RBCs are recommended for all the patients to reduce the incidence of febrile and urticarial reactions as well as infectious cytomegalovirus contamination.
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The main advantages of early initiation of blood transfusion in patient thalassemia are to avoid further progression of the disease and also to prevent or ameliorate its associated complications. Today, however, thanks to blood transfusion therapy and effective iron chelators, the life expectancy for children with severe <a href="http://treatment-thalassemia.blogspot.com/">thalassemia</a> is constantly improving.</div>
cantikhttp://www.blogger.com/profile/04413983402238496919noreply@blogger.com0tag:blogger.com,1999:blog-1796222896024052559.post-60639755906058905222011-07-20T21:53:00.004+03:002012-03-19T00:19:45.219+03:00Information About Thalassemia Disease<div dir="ltr" style="text-align: left;" trbidi="on">Thalassemia disease is a group of inherited autosomal recessive blood disorders, in which the body makes an abnormal form of hemoglobin, the protein in red blood cells that carries oxygen thus causing anemia, the characteristic presenting symptom of the <a href="http://en.wikipedia.org/wiki/Thalassemia" style="color: #444444;" target="_blank">thalassemias</a>.<br />
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Thalassemia in British English written with the spelling of thalassaemia, history of <a href="http://disease-treatment.blogspot.com/2011/08/disease-and-treatment-of-thalassemia.html">thalassemia disease</a> was originated in the Mediterranean region. It is an area at the lands around the Mediterranean Sea that have a Mediterranean climate, with mild, rainy winters and hot, dry summers. In the geography, It covers portions of three continents ; Europe, Asia, and Africa.<br />
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In the thalassemias cases, parents pass the genes for the disorder on to their children. Thalassemias usually result in underproduction of normal globin proteins, often through mutations in regulatory genes.<br />
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There are two main types of thalassemia :<br />
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<ul style="text-align: left;"><li>Alpha (α) thalassemia occurs when a gene or genes related to the alpha globin protein are missing or changed (mutated). The α thalassemias involve the genes HBA1 and HBA2, inherited in a Mendelian recessive fashion.</li>
<li>Beta thalassemia occurs when similar gene defects affect production of the beta globin protein. Beta thalassemias are due to mutations in the HBB gene on chromosome 11, It's also inherited in an autosomal-recessive fashion.</li>
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From types of thalassemia disease above, there are two forms of <a href="http://www.medicinenet.com/alpha_thalassemia/article.htm" style="color: #444444;" target="_blank">thalassemia</a> including Thalassemia major (the thalassemia is transmitted from the defective gene of both parents) and Thalassemia minor (It is occurs if you receive the defective gene from only one parent). Beta thalassemia major is also called Cooley's anemia.<br />
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Signs and symptoms of thalassemia :<br />
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Signs and symptoms of thalassemia disease depend on the type and severity of thalassemia case on patient. The most severe form of alpha thalassemia major causes stillbirth (death of the unborn baby during birth or the late stages of pregnancy). Some babies show signs and symptoms of thalassemia at birth, while others may develop signs or symptoms during the first two years of life.<br />
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Generally, sign and symptoms of thalassemia disease are Fatigue, Weakness, Shortness of breath, Irritability, Yellow discoloration of skin (jaundice), Pale appearance, Facial bone deformities, Abdominal swelling, Slow growth, and Dark urine<br />
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Examinations, Test and Diagnosis of Thalassemia Disease :<br />
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In the examination, may doctor will check is there any swollen (enlarged) on patient's spleen by palpation test. A blood sample will be taken and sent to a laboratory for examination of complete blood count (CBC), Red blood cells (RBC), and hemoglobin electrophoresis.<br />
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There is also test called mutational analysis, it can help detect alpha thalassemia that cannot be seen with hemoglobin electrophoresis. If the result is CBC appear as anemia, appear small and abnormally shaped on the RBC, and presence of an abnormal form of hemoglobin, the medical team or the doctor will put suspect of thalassemia case.<br />
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<a href="http://treatment-thalassemia.blogspot.com/">Management or treatment of Thalassemia disease</a> :<br />
<ul style="text-align: left;"><li>Regular blood transfusions and folate supplements</li>
<li>Stem cell or bone marrow transplant</li>
<li>Giving medication therapy which can reduce sign and symptom may appear</li>
</ul></div>cantikhttp://www.blogger.com/profile/04413983402238496919noreply@blogger.com0